{"product_id":"glk-g4-polyclonal-antibody-bs2755","title":"GLK (G4) Polyclonal Antibody-BS2755","description":"\u003cp\u003eGLK (G4) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2755-50, BS2755-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Mitogen-activated protein kinase kinase kinase kinase 3; MAPK\/ERK kinase kinase kinase 3; MEK kinase kinase 3; Germinal center kinase related protein kinase; MEKKK 3; MAP4K3\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q8IVH8\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine\/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include GLK, KHS, NIK, YSK1, HPK1, Krs-1, Krs-2 and human GC kinase. GLK (for GC-like kinase) is an 885 amino acid protein that shares a high degree of homology with GC kinase and HPK1. Like many of the STE20-like kinases, GLK specifically activates\u003cbr\u003e\nthe JNK pathway. Epistasis studies with dominant negative mutants of MEKK1 suggest that GLK functions upstream of MEKK1 in the JNK signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: GLK (G4) polyclonal antibody detects endogenous levels of GLK protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 65 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of GLK (G4) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: HEK293T whole cell lysate\u003cbr\u003e\nLane 2: sp2\/0 whole cell lysate\u003cbr\u003e\nLane 3: H9C2 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to the N-terminal of Human GLK.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911798100147,"sku":"BS2755-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911798132915,"sku":"BS2755-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_c5730b62-9caf-4754-9877-834598bf5cc9.jpg?v=1703179397","url":"https:\/\/afsbio.com\/products\/glk-g4-polyclonal-antibody-bs2755","provider":"AFSBio Inc.","version":"1.0","type":"link"}