{"product_id":"glucocorticoid-receptor-recombinant-rabbit-monoclonal-antibody-bs45446","title":"Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody - BS45446","description":"\u003cp\u003eGlucocorticoid Receptor Recombinant Rabbit mAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS45446-50, BS45446-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regμlator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellμlar proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene resμlts in transcript variants encoding either the same or different isoforms. Additional isoforms resμlting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC\/IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GR, GCR, GRL, GCCR, GCRST\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of mouse Glucocorticoid Receptor\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:1000 IHC: 1:500-1:2000 ICC\/IF: 1:200-1:500 FC: 1:200-1:500\u003c\/p\u003e\n\n\u003cp\u003ePurification: Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 94, 91 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P06537\u003c\/p\u003e\n\n\u003cp\u003eProduct: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45937185751219,"sku":"BS45446-50","price":424.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45937185783987,"sku":"BS45446-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/glucocorticoid-receptor-recombinant-rabbit-monoclonal-antibody-bs45446","provider":"AFSBio Inc.","version":"1.0","type":"link"}