{"product_id":"glur-2-polyclonal-antibody-ra25354","title":"GluR-2 Polyclonal Antibody - RA25354","description":"GluR-2 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA25354-50, RA25354-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: glutamate ionotropic receptor AMPA type subunit 2 (GRIA2) Homo sapiens Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-\u0026gt;CGG; Q-\u0026gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca (2+) . Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q\/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants enco\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: GRIA2; GLUR2; Glutamate receptor 2; GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic; AMPA 2; GluA2\n\nApplications: WB; IHC-p; IF\/ICC; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 2891\n\nProtein MW (KDa): 99\n\nSWISS: P42262\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121296761011,"sku":"RA25354-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121296793779,"sku":"RA25354-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3dd789b5-db4c-4196-91f3-b2be9525846f.png?v=1773346175","url":"https:\/\/afsbio.com\/products\/glur-2-polyclonal-antibody-ra25354","provider":"AFSBio Inc.","version":"1.0","type":"link"}