{"product_id":"glur1-phospho-s863-polyclonal-antibody-bs4793","title":"GluR1 (phospho-S863) Polyclonal Antibody-BS4793","description":"\u003cp\u003eGluR1 (phospho-S863) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4793-50, BS4793-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P42261\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eGluR1 (phospho-S863) Polyclonal Antibody-BS4793\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate\/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate\/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate\/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-GluR1 (S863) polyclonal antibody detects endogenous levels of GluR1 protein only when phosphorylated at Ser863.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 102 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of p-GluR1 (S863) pAb pAb at 1:500 dilution\u003cbr\u003e\n Lane 1: HEK293T whole cell lysate (40ug) \u003cbr\u003e\n Lane 2: K562 whole cell lysate (40ug) \u003cbr\u003e\n Lane 3: U-87MG whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of p-GluR1 (S863) pAb pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; GluRA; GluRK1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human GluR1 around the phosphorylation site of Serine 863.\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957298466995,"sku":"BS4793-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957298499763,"sku":"BS4793-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_0143c05f-fc0d-4a92-9803-f29c293dc84b.jpg?v=1705144538","url":"https:\/\/afsbio.com\/products\/glur1-phospho-s863-polyclonal-antibody-bs4793","provider":"AFSBio Inc.","version":"1.0","type":"link"}