{"product_id":"glur4-glua4-gria4-rabbit-pab-a1492","title":"GluR4\/GluA4\/GRIA4 Rabbit pAb - A1492","description":"GluR4\/GluA4\/GRIA4 Rabbit pAb\n\nSizes: 20μL, 100μL\n\nCatalogue Numbers: A1492-20, A1492-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA-\u0026gt;GGA; R-\u0026gt;G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.\n\nCategory: Polyclonal Antibodies\n\nApplications: WB, ELISA\n\nCross-reactivity: Human, Mouse, Rat\n\nProtein Weight: 101kDa\n\nObserved Molecular Weight: 101kDa\n\nImmunogen: Recombinant protein (or fragment)\n\nSpecies: Human\n\nGeneID: 2893\n\nSWISS: P48058\n\nAlternate Names: GLUR4; GLURD; GluA4; GLUR4C; NEDSGA; GluA4-ATD; GluR4\/GluA4\/GRIA4\n\nSource: Rabbit\n\nIsotype: IgG\n\nPurity: Affinity purification\n\nStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\n\nRecommended Dilutions: WB, 1:1000 - 1:4000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\n\nResearch Areas: Signal Transduction, G protein signaling, G-Protein-Coupled ReceptorsGPCR, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Dopamine Signaling in Parkinson's Disease.\n\nNCBI Alias: GRIA4\n\nResearch Use Only","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189613486259,"sku":"A1492-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189613519027,"sku":"A1492-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_1a0b7ac1-6d9e-4bdb-a84a-90bb6c61e462.png?v=1766431017","url":"https:\/\/afsbio.com\/products\/glur4-glua4-gria4-rabbit-pab-a1492","provider":"AFSBio Inc.","version":"1.0","type":"link"}