{"product_id":"gnl3l-polyclonal-antibody-bs62387","title":"GNL3L Polyclonal Antibody-BS62387","description":"\u003cp\u003eGNL3L Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62387-50, BS62387-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9NVN8\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000 IHC:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Guanine nucleotide-binding protein-like 3-like protein, stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The protein was purified from E.coli and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: GNL3L polyclonal antibody detects endogenous levels of GNL3L protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of GNL3L polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:H1792 whole cell lysate\u003cbr\u003e\nLaneB:MCF-7 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 72 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Guanine nucleotide-binding protein-like 3-like protein; GNL3L\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human GNL3L.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910454874291,"sku":"BS62387-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910454907059,"sku":"BS62387-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_8df5d269-394c-41fc-8386-53a90d9684a2.jpg?v=1703092729","url":"https:\/\/afsbio.com\/products\/gnl3l-polyclonal-antibody-bs62387","provider":"AFSBio Inc.","version":"1.0","type":"link"}