{"product_id":"gpr109a-hm74a-hcar2-polyclonal-antibody-e-ab-93136","title":"GPR109A\/HM74A\/HCAR2 Polyclonal Antibody - E-AB-93136","description":"\u003cp\u003eGPR109A\/HM74A\/HCAR2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93136-60, E-AB-93136-120, E-AB-93136-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GPR109A\/HM74A\/HCAR2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: HCAR2; GPR109A; HCA2; HM74a; HM74b; NIACR1; PUMAG; Puma-g\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology, Cardiovascular, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q8TDS4\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid \u0026gt; acifran \u0026gt; 5-methyl nicotinic acid = acipimox \u0026gt;\u0026gt; nicotinuric acid = nicotinamide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human GPR109A\/HM74A\/HCAR2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 42kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 44KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146679746739,"sku":"E-AB-93136-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146679779507,"sku":"E-AB-93136-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146679812275,"sku":"E-AB-93136-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ce8d6126-3eba-40c0-ac28-e90b3b0ebe11.png?v=1710299990","url":"https:\/\/afsbio.com\/products\/gpr109a-hm74a-hcar2-polyclonal-antibody-e-ab-93136","provider":"AFSBio Inc.","version":"1.0","type":"link"}