{"product_id":"graf-polyclonal-antibody-bs65676","title":"GRAF Polyclonal Antibody-BS65676","description":"\u003cp\u003eGRAF Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65676-50, BS65676-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UNA1\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat,Chicken,Dog, Pig, Cow, Rabbit, Sheep,\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL\/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: GRAF Polyclonal Antibody detects endogenous levels of GRAF protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 38 kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Sample:\u003cbr\u003e\n Cerebrum(Rat) Lysate at 40 ug\u003cbr\u003e\n Cerebrum(Mouse) Lysate at 40 ug\u003cbr\u003e\n Cerebellum(Rat) Lysate at 40 ug\u003cbr\u003e\n HepG2(Human) Cell Lysate at 30 ug\u003cbr\u003e\n Kidney(Rat) Lysate at 40 ug\u003cbr\u003e\n Kidney(Mouse) Lysate at 40 ug\u003cbr\u003e\n A549(Human) Cell Lysate at 30 ug\u003cbr\u003e\n A431(Human) Cell Lysate at 30 ug\u003cbr\u003e\n HL60(Human) Cell Lysate at 30 ug\u003cbr\u003e\n U937(Human) Cell Lysate at 30 ug\u003cbr\u003e\n Cerebellum(Mouse) Lysate at 40 ug\u003cbr\u003e\n Primary: Anti-GRAF at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26.\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human GRAF1\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43029547483315,"sku":"BS65676-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43029547516083,"sku":"BS65676-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_8d736b12-c3e3-4745-a6d8-bca27ed28bdd.jpg?v=1707221513","url":"https:\/\/afsbio.com\/products\/graf-polyclonal-antibody-bs65676","provider":"AFSBio Inc.","version":"1.0","type":"link"}