{"product_id":"grap-polyclonal-antibody-e-ab-18391","title":"GRAP Polyclonal Antibody - E-AB-18391","description":"\u003cp\u003eGRAP Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-18391-60, E-AB-18391-120, E-AB-18391-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GRAP\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Grap; GRAP; GRB2 related adaptor protein; GRB2-related adapter protein; Growth factor receptor bound protein 2 related adaptor protein; MGC64880; OTTHUMP00000065766\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q13588\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the GRB2\/Sem5\/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.7 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Full length fusion protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130689323187,"sku":"E-AB-18391-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130689355955,"sku":"E-AB-18391-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130689388723,"sku":"E-AB-18391-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_eed4d245-634b-4944-9ebf-41d96ec0d5c9.png?v=1709811407","url":"https:\/\/afsbio.com\/products\/grap-polyclonal-antibody-e-ab-18391","provider":"AFSBio Inc.","version":"1.0","type":"link"}