{"product_id":"grem1-polyclonal-antibody-e-ab-14111","title":"GREM1 Polyclonal Antibody - E-AB-14111","description":"\u003cp\u003eGREM1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-14111-60, E-AB-14111-120, E-AB-14111-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GREM1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: BMP antagonist 1; Cell proliferation inducing gene 2 protein; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1; Cysteine knot superfamily 1; BMP antagonist 1; Cysteine knot superfamily BMP antagonist 1; DAN domain family member 2; DAND2; Down regulated in Mos-transformed cells protein; Down-regulated in Mos-transformed cells protein; DRM; grem1; GREM1; Gremlin 1 homolog; cysteine knot superfamily; Gremlin 1 like protein; Gremlin 1; cysteine knot superfamily; homolog; GREMLIN; Gremlin-1; Gremlin1; IHG-2; IHG2; Increased in high glucose 2; Increased in high glucose protein 2; PIG2; Proliferation inducing gene 2; proliferation inducing gene 2 protein\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O60565\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.3 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human GREM1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21kDa\u003c\/p\u003e\n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43136350814387,"sku":"E-AB-14111-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43136350847155,"sku":"E-AB-14111-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43136350912691,"sku":"E-AB-14111-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_cf1e09a2-4294-4e10-9ffe-0d3941735428.png?v=1709989333","url":"https:\/\/afsbio.com\/products\/grem1-polyclonal-antibody-e-ab-14111","provider":"AFSBio Inc.","version":"1.0","type":"link"}