{"product_id":"grk-2-monoclonal-antibody-bt-mca0630","title":"GRK 2 Monoclonal Antibody - BT-MCA0630","description":"\u003cp\u003eGRK 2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0630-50, BT-MCA0630-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ADRBK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ICC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat,Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Beta-adrenergic receptor kinase 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P25098; Mouse: Q99MK8; Rat: P26817\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 15625238\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238710304947,"sku":"BT-MCA0630-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238710337715,"sku":"BT-MCA0630-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b20d464d-0fee-422a-a61f-1b8697d32dfa.png?v=1769383991","url":"https:\/\/afsbio.com\/products\/grk-2-monoclonal-antibody-bt-mca0630","provider":"AFSBio Inc.","version":"1.0","type":"link"}