{"product_id":"grk2-phospho-tyr86-polyclonal-antibody-bt-ap15790","title":"GRK2 (Phospho-Tyr86) Polyclonal Antibody - BT-AP15790","description":"\u003cp\u003eGRK2 (Phospho-Tyr86) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15790-20, BT-AP15790-50, BT-AP15790-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ADRBK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: GRK2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P25098\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GRK2;Phospho-Tyr86; Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 156\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239159455923,"sku":"BT-AP15790-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239159488691,"sku":"BT-AP15790-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239159521459,"sku":"BT-AP15790-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_cc1690c9-8557-4440-aec7-51428e8c9e79.png?v=1769389929","url":"https:\/\/afsbio.com\/products\/grk2-phospho-tyr86-polyclonal-antibody-bt-ap15790","provider":"AFSBio Inc.","version":"1.0","type":"link"}