{"product_id":"gshb-rabbit-polyclonal-antibody-es11903","title":"GSHB Rabbit Polyclonal Antibody - ES11903","description":"\u003cp\u003eGSHB Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11903-50, ES11903-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: GSHB,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: GSHB Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Fetal brain cortex, Kidney, Lung,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 52kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Cysteine and methionine metabolism, Glutathione metabolism, Metabolic pathways, Biosynthesis of cofactors, Ferroptosis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. Disease: Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:266130]; referred to as 5-oxoprolinuria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Disease: Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes [MIM:231900]. It is a mild form causing hemolytic anemia. pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2\/2. Similarity: Belongs to the eukaryotic GSH synthase family. Subunit: Homodimer.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: cytosol, extracellular exosome,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: GSS\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Glutathione synthetase, GSH synthetase, GSH-S, EC 6.3.2.3, Glutathione synthase\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 2937\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P48637\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P51855\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P46413\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825499955379,"sku":"ES11903-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825499988147,"sku":"ES11903-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/gshb-rabbit-polyclonal-antibody-es11903","provider":"AFSBio Inc.","version":"1.0","type":"link"}