{"product_id":"gsk3α-β-phospho-y279-216-polyclonal-antibody-bs4083","title":"GSK3α\/β (phospho-Y279\/216) Polyclonal Antibody - BS4083","description":"\u003cp\u003eGSK3α\/β (phospho-Y279\/216) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4083-50, BS4083-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycogen synthase kinase-3 α and β (GSK-3α, β) are serine\/threonine kinases that regμlate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine\/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimμlation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively through a phosphatidylinositol 3-kinase (PI 3-kinase)-protein kinase B (PKB) dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine\/threonine-protein kinase GSK3A, GSK3A\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human GSK3α around the phosphorylation site of Tyrosine 279.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:2000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-GSK3α\/β (Y279\/216) polyclonal antibody detects endogenous levels of GSK3α\/β protein only when phosphorylated at Tyr279\/216\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 46, 51 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: PI3K AKT signaling, Hedgehog Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Translational Contral Regμlation of elF2, Regμlation of Microtubμle Dynamics, Inhibition of Apoptosis, Insμlin \u0026amp;Glucose Signaling, Cell Cycle Control G1 S Checkpoint,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P49840\/P49841\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946277036211,"sku":"BS4083-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946277068979,"sku":"BS4083-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/gsk3%ce%b1-%ce%b2-phospho-y279-216-polyclonal-antibody-bs4083","provider":"AFSBio Inc.","version":"1.0","type":"link"}