{"product_id":"gsk3-alpha-beta-polyclonal-antibody-e-ab-31628","title":"GSK3 alpha\/beta Polyclonal Antibody - E-AB-31628","description":"\u003cp\u003eGSK3 alpha\/beta Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-31628-60, E-AB-31628-120, E-AB-31628-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GSK3α\/β\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: GSK3A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; Serine\/threonine-protein kinase GSK3A; GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine\/threonine-protein kinase GSK3B\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Neuroscience, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P49840,P49841\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine\/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase\/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human GSK3α\/β around the non-phosphorylation site of Tyr279\/216.\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 51kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 51,46kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146012426419,"sku":"E-AB-31628-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146012459187,"sku":"E-AB-31628-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146012491955,"sku":"E-AB-31628-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_6baf0b0e-8c02-443a-968e-2abfff89857f.png?v=1710289783","url":"https:\/\/afsbio.com\/products\/gsk3-alpha-beta-polyclonal-antibody-e-ab-31628","provider":"AFSBio Inc.","version":"1.0","type":"link"}