{"product_id":"gsk3-alpha-monoclonal-antibody-bt-mca3051","title":"GSK3 alpha Monoclonal Antibody - BT-MCA3051","description":"\u003cp\u003eGSK3 alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3051-50, BT-MCA3051-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycogen synthase kinase 3 alpha belongs to the Ser\/Thr family of protein kinases, Cdc2\/cdkx subfamily,GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GSK3 alpha\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6G12C2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: GSK3 alpha\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of GSK3 alpha expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P49840\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DKFZp686D0638, GSK3A\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2931\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238375153843,"sku":"BT-MCA3051-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238375186611,"sku":"BT-MCA3051-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1a53bbd0-d107-4b28-9c5c-778433895081.png?v=1769379443","url":"https:\/\/afsbio.com\/products\/gsk3-alpha-monoclonal-antibody-bt-mca3051","provider":"AFSBio Inc.","version":"1.0","type":"link"}