{"product_id":"gsk3-beta-monoclonal-antibody-mb66643","title":"GSK3 beta Monoclonal Antibody - MB66643","description":"\u003cp\u003eGSK3 beta Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66643-50, MB66643-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regμlates glycogen synthesis in response to insμlin. GSK-3 is a ubiquitously expressed serine\/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K\/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regμlation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regμlate cyclin D1 proteolysis and subcellμlar localization.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine\/threonine-protein kinase GSK3B\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human GSK3B (AA: 2-159) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/100), FC (1\/50 - 1\/100)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of GSK3 beta protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 46 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer\\'s Disease, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Cell Cycle Control G1 S Checkpoin, MAPK Erk in Growth and Differentiation Pathway, Hedgehog Signaling, Inhibition of Apoptosis, Insμlin \u0026amp;Glucose Signaling, Regμlation of Microtubμle Dynamics, NF-kB Signaling, PI3K AKT signaling, Translational Contral Regμlation of elF2, Translational Contral elF4 and p70 S6 Kinase, Wntβ catenin signaling, MTOR signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P49841\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946415448243,"sku":"MB66643-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946415481011,"sku":"MB66643-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/gsk3-beta-monoclonal-antibody-mb66643","provider":"AFSBio Inc.","version":"1.0","type":"link"}