{"product_id":"gtpase-kras-polyclonal-antibody-e-ab-40639","title":"GTPase Kras Polyclonal Antibody - E-AB-40639","description":"\u003cp\u003eGTPase Kras Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40639-50, E-AB-40639-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: KRAS\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: KRAS; KRAS2; RASK2; GTPase Kras; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase Kras\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P01116\u003c\/p\u003e\n\n\u003cp\u003eBackground: KRAS, also called p21, is a member of the Ras superfamily of proteins. It is located on human chromosome 12, and contains four coding exons and a 5' non-coding exon (PMID: 12778136). KRAS is a membrane-anchored guanosine triphosphate\/guanosine diphosphate (GTP\/GDP)-binding protein and is widely expressed in most human cells. Like other members of the Ras family, the KRAS protein is a GTPase, and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687). KRAS mutations have been found in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 2.5mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human KRAS protein expressed by E.coli.\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 21 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149047365811,"sku":"E-AB-40639-50","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149047398579,"sku":"E-AB-40639-100","price":322.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ec164e80-b92a-4e2c-8eb4-bc7ff7b88e2b.png?v=1710339208","url":"https:\/\/afsbio.com\/products\/gtpase-kras-polyclonal-antibody-e-ab-40639","provider":"AFSBio Inc.","version":"1.0","type":"link"}