{"product_id":"gtpbp4-polyclonal-antibody-e-ab-62398","title":"GTPBP4 Polyclonal Antibody - E-AB-62398","description":"\u003cp\u003eGTPBP4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62398-60, E-AB-62398-120, E-AB-62398-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GTPBP4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: GTPBP4; CRFG; NGB; NOG1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9BZE4\u003c\/p\u003e\n\n\u003cp\u003eBackground: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human GTPBP4 (NP_036473.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:1000-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 60kDa\/68kDa\/73kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 74kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146241540275,"sku":"E-AB-62398-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146241573043,"sku":"E-AB-62398-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146241605811,"sku":"E-AB-62398-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_53e1a2fa-3521-4559-bcef-b8e6d5a353d9.png?v=1710292241","url":"https:\/\/afsbio.com\/products\/gtpbp4-polyclonal-antibody-e-ab-62398","provider":"AFSBio Inc.","version":"1.0","type":"link"}