{"product_id":"hap1-polyclonal-antibody-bt-ap09814","title":"HAP1 Polyclonal Antibody - BT-AP09814","description":"\u003cp\u003eHAP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09814-20, BT-AP09814-50, BT-AP09814-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Huntingtonandapos;s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Epigenetics and nuclear signaling; Cancer; Cell biology; Metabolism; Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: HAP1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Huntingtin-associated protein 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P54257; Mouse: O35668; Rat: P54256\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Huntingtin-associated protein 1;HAP-1;Neuroan 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9001\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239162536115,"sku":"BT-AP09814-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239162568883,"sku":"BT-AP09814-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239162601651,"sku":"BT-AP09814-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_89f75ec0-d9d4-450f-9ffc-a9f5e841a7de.png?v=1769389970","url":"https:\/\/afsbio.com\/products\/hap1-polyclonal-antibody-bt-ap09814","provider":"AFSBio Inc.","version":"1.0","type":"link"}