{"product_id":"hat1-polyclonal-antibody-bs1650","title":"HAT1 Polyclonal Antibody-BS1650","description":"\u003cp\u003eHAT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1650-100, BS1650-1ml\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100µl, 1ml\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O14929\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: In the intact cell, DNA closely associates with histones and other nuclear\u003cbr\u003e\nproteins to form chromatin. The remodeling of chromatin is believed to be\u003cbr\u003e\na critical component of transcriptional regulation and a major source of this\u003cbr\u003e\nremodeling is brought about by the acetylation of nucleosomal histones.\u003cbr\u003e\nAcetylation of lysine residues in the amino-terminal tail domain of histone\u003cbr\u003e\nresults in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including\u003cbr\u003e\nGCN5, PCAF (p300\/CBP-associated factor), p300\/CBP, HAT1 and the TFIID\u003cbr\u003e\nsubunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2\u003cbr\u003e\n(also designated RPD3) and HDAC3-6 have been identified as histone\u003cbr\u003e\ndeacetylases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HAT1 polyclonal antibody detects endogenous levels of HAT1 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of HAT1 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane1:EC9706 whole cell lysate(40ug)\u003cbr\u003e\nLane2:SGC7901 whole cell lysate(40ug)\u003cbr\u003e\nLane3:HCT116 whole cell lysate(40ug)\u003cbr\u003e\nLane4:CT-26 whole cell lysate(40ug)\u003cbr\u003e\nLane5:PC12 whole cell lysate(40ug)\u003c\/p\u003e\n\n\n\u003cp\u003eBioworld Molecular Weight: ~ 48 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Histone acetyltransferase 1; HAT1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human HAT1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"100µl","offer_id":42908774564019,"sku":"BS1650-100","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"1ml","offer_id":42908774596787,"sku":"BS1650-1ml","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_63f3211f-dca3-4888-93c5-83ba52172a5b.jpg?v=1703006917","url":"https:\/\/afsbio.com\/products\/hat1-polyclonal-antibody-bs1650","provider":"AFSBio Inc.","version":"1.0","type":"link"}