{"product_id":"hat1-polyclonal-antibody-bs7954","title":"HAT1 Polyclonal Antibody-BS7954","description":"\u003cp\u003eHAT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7954-50, BS7954-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O14929\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF CHIP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000 \u003cbr\u003e\nIHC\/IF: 1:50~1:200\u003cbr\u003e\nCHIP: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300\/CBP-associated factor), p300\/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HAT1 polyclonal antibody detects endogenous levels of HAT1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 49 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: WesternBlot (WB) analysis of HAT1 polyclonal antibody, Immunofluorescence analysis of U2OS cells, using HAT1 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1; HAT1; KAT1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human HAT1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42989564690611,"sku":"BS7954-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42989564723379,"sku":"BS7954-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5765353a-0e68-4c2c-8c04-e1acc55d7c23.jpg?v=1706095433","url":"https:\/\/afsbio.com\/products\/hat1-polyclonal-antibody-bs7954","provider":"AFSBio Inc.","version":"1.0","type":"link"}