{"product_id":"hbo1-rabbit-pab-es2494","title":"HBO1 rabbit pAb - ES2494","description":"\u003cp\u003eHBO1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2494-50, ES2494-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L., domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction., function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MYST (SAS\/MOZ) family., similarity:Contains 1 C2HC-type zinc finger., subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2\/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone., tissue specificity:Ubiquitously expressed, with highest levels in testis.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2\/SAS3, SAS2 and TIP60 protein 2; MYST-2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MYST2. AA range:131-180\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 75kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 11143\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O95251\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytosol. Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055). Localizes to transcription start sites (PubMed:21753189, PubMed:24065767). Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581). Localizes to centromeres in G1 phase (PubMed:27270040).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202080268467,"sku":"ES2494-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202080301235,"sku":"ES2494-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_8456489f-b4cc-4dd0-96fe-99046bc2b6f8.png?v=1767121410","url":"https:\/\/afsbio.com\/products\/hbo1-rabbit-pab-es2494","provider":"AFSBio Inc.","version":"1.0","type":"link"}