{"product_id":"hdac4-polyclonal-antibody-bt-ap03923","title":"HDAC4 Polyclonal Antibody - BT-AP03923","description":"\u003cp\u003eHDAC4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03923-20, BT-AP03923-50, BT-AP03923-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation\/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 4 encoded by HDAC4 belongs to class II of the histone deacetylase\/acuc\/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. Histone deacetylase 4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: HDAC4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: HDAC4 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 119070\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P56524; Mouse: Q6NZM9; Rat: Q99P99\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HDAC4; KIAA0288; Histone deacetylase 4; HD4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9759; Mouse: 208727; Rat: 363287\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240353947827,"sku":"BT-AP03923-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240353980595,"sku":"BT-AP03923-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240354013363,"sku":"BT-AP03923-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c4e02408-7555-4c83-ba09-fc4b80cb05ab.png?v=1769407254","url":"https:\/\/afsbio.com\/products\/hdac4-polyclonal-antibody-bt-ap03923","provider":"AFSBio Inc.","version":"1.0","type":"link"}