{"product_id":"hdac5-polyclonal-antibody-bt-ap03924","title":"HDAC5 Polyclonal Antibody - BT-AP03924","description":"\u003cp\u003eHDAC5 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03924-20, BT-AP03924-50, BT-AP03924-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation\/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 5 encoded by HDAC5 belongs to the class II histone deacetylase\/acuc\/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. HDAC5 is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for HDAC5.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: HDAC5\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: HDAC5 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 121992\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9UQL6; Mouse: Q9Z2V6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10014\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240354046131,"sku":"BT-AP03924-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240354078899,"sku":"BT-AP03924-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240354111667,"sku":"BT-AP03924-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3654b053-d535-47cf-980e-72b4c361b242.png?v=1769407257","url":"https:\/\/afsbio.com\/products\/hdac5-polyclonal-antibody-bt-ap03924","provider":"AFSBio Inc.","version":"1.0","type":"link"}