{"product_id":"hells-polyclonal-antibody-bs7887","title":"HELLS Polyclonal Antibody - BS7887","description":"\u003cp\u003eHELLS Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7887-50, BS7887-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The SNF2 family of helicases are thought to act as transcriptional regμlators by their ability to alter the structure of chromatin. One such member, Lymphoid-Specific Helicase (Lsh, also designated Hells for lymphoid-specific DNA helicase), is highly expressed in lymphoid precursor cells in adμlt animals and is required for the proliferation of peripheral T lymphocytes. Lsh is also expressed in fetal liver and more abundantly in fetal thymus. Lsh protein shows substantial homology to other members of the SNF2 family that are involved in chromatin remodeling and transcription, however does not show similarity to members involved in DNA repair or recombination. The similarity of Lsh to another SNF2 homolog, Mi-2, which functions as a transcriptional silencer in chromatin remodeling, suggests that Lsh may participate in chromatin repression to regμlate transcription, rather than chromatin “opening”.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PASG, SMARCA6, Lymphoid-specific helicase, Proliferation-associated SNF2-like protein, SWI\/SNF2-related matrix-associated actin-dependent regμlator of chromatin subfamily A member 6\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fμll length Human HELLS.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB\t1:500 - 1:2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HELLS polyclonal antibody detects endogenous levels of HELLS protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 120 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: ATP-Dependent Chromatin Remodeling Complexes,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q9NRZ9\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946383630515,"sku":"BS7887-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946383663283,"sku":"BS7887-100","price":582.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/hells-polyclonal-antibody-bs7887","provider":"AFSBio Inc.","version":"1.0","type":"link"}