{"product_id":"her2-monoclonal-antibody-11h9-ra10577","title":"HER2 Monoclonal Antibody (11H9) - RA10577","description":"\u003cp\u003eHER2 Monoclonal Antibody (11H9)\u003c\/p\u003e \n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA10577-50, RA10577-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: erb-b2 receptor tyrosine kinase 2 (ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654\/Ile655, shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d\u003c\/p\u003e\n\n\u003cp\u003eCondition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IF\/ICC; IHC-p\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 2064\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 180\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P04626\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119015714995,"sku":"RA10577-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119015747763,"sku":"RA10577-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ad854993-54ba-488b-806f-173b16a7fcd2.png?v=1773344292","url":"https:\/\/afsbio.com\/products\/her2-monoclonal-antibody-11h9-ra10577","provider":"AFSBio Inc.","version":"1.0","type":"link"}