{"product_id":"her2-phospho-tyr1139-polyclonal-antibody-bt-ap06593","title":"HER2 (Phospho-Tyr1139) Polyclonal Antibody - BT-AP06593","description":"\u003cp\u003eHER2 (Phospho-Tyr1139) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06593-20, BT-AP06593-50, BT-AP06593-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654\/Ile655| shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Signal transduction; Tags and cell markers; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ERBB2\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: HER2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P04626\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HER2;Phospho-Tyr1139; Receptor tyrosine-protein kinase erbB-2; EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2064\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238972776627,"sku":"BT-AP06593-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238972809395,"sku":"BT-AP06593-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238972842163,"sku":"BT-AP06593-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d5045c10-1bec-4c30-b691-0726605d024b.png?v=1769387402","url":"https:\/\/afsbio.com\/products\/her2-phospho-tyr1139-polyclonal-antibody-bt-ap06593","provider":"AFSBio Inc.","version":"1.0","type":"link"}