{"product_id":"her4-erbb4-phospho-tyr984-rabbit-polyclonal-antibody-bt-ap02965","title":"HER4\/ErbB4 (Phospho-Tyr984) Rabbit Polyclonal Antibody - BT-AP02965","description":"\u003cp\u003eHER4\/ErbB4 (Phospho-Tyr984) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02965-20, BT-AP02965-50, BT-AP02965-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains| a transmembrane domain| a tyrosine kinase domain| a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however| not all variants have been fully characterized.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Signal transduction; Tags and cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ERBB4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: HER4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q15303; Mouse: Q61527; Rat: Q62956\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HER4\/ErbB4;Tyr984; Receptor tyrosine-protein kinase erbB-4; EC 2.7.10.1; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; ERBB4 intracellular domain; 4ICD; E4ICD; s80HER4;\u003c\/p\u003e \n\n\u003cp\u003eGeneID: Human: 2066; Mouse: 13869; Rat: 59323\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238998827187,"sku":"BT-AP02965-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238998859955,"sku":"BT-AP02965-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238998892723,"sku":"BT-AP02965-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_16749663-92fd-4538-92ca-0c8e05256ad7.png?v=1769387752","url":"https:\/\/afsbio.com\/products\/her4-erbb4-phospho-tyr984-rabbit-polyclonal-antibody-bt-ap02965","provider":"AFSBio Inc.","version":"1.0","type":"link"}