{"product_id":"hes2-polyclonal-antibody-bt-ap09870","title":"HES2 Polyclonal Antibody - BT-AP09870","description":"\u003cp\u003eHES2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09870-20, BT-AP09870-50, BT-AP09870-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho\/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,Transcriptional repressor of genes that require a bHLH protein for their transcription.,Contains 1 basic helix-loop-helix (bHLH) domain.,Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho\/TLE family.,tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: HES2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Transcription factor HES-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9Y543; Mouse: O54792; Rat: P35429\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Transcription factor HES-2;Class B basic helix-loop-helix protein 40;bHLHb40;Hairy and enhancer of split 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 54626\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239165321395,"sku":"BT-AP09870-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239165354163,"sku":"BT-AP09870-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239165386931,"sku":"BT-AP09870-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_cbae64e2-31cb-41cc-8e8b-0394db3a0c7c.png?v=1769390015","url":"https:\/\/afsbio.com\/products\/hes2-polyclonal-antibody-bt-ap09870","provider":"AFSBio Inc.","version":"1.0","type":"link"}