{"product_id":"hgk-r430-polyclonal-antibody-bs2249","title":"HGK (R430) Polyclonal Antibody-BS2249","description":"\u003cp\u003eHGK (R430) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:BS2249-50, BS2249-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O95819\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine\/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include NIK, KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, and GC kinase. NIK (Nck interacting kinase), like many of the STE20-like kinases, has been shown to activate the SAPK\/JNK stress response pathway. Both the kinase domain and the C-terminal regulatory domain of NIK are required for full activation. NIK interacts with MEKK1 and is thought to act upstream of MEKK1 in the SAPK\/JNK signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 142 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HGK (R430) polyclonal antibody detects endogenous levels of HGK protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: Mitogen-activated protein kinase kinase kinase kinase 4; MAPK\/ERK kinase kinase kinase 4; MEK kinase kinase 4; HPK\/GCK-like kinase HGK; Nck interacting kinase; MEKKK 4; MAP4K4; NIK; KIAA0687\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 411-460 of Human HGK.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895065022643,"sku":"BS2249-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895065055411,"sku":"BS2249-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_2c6a3f41-7d20-43e2-b4d2-ec8ac49c166a.jpg?v=1702573202","url":"https:\/\/afsbio.com\/products\/hgk-r430-polyclonal-antibody-bs2249","provider":"AFSBio Inc.","version":"1.0","type":"link"}