{"product_id":"histamine-h1-receptor-phospho-ser398-rabbit-polyclonal-antibody-es5776","title":"Histamine H1 Receptor (phospho Ser398) Rabbit Polyclonal Antibody - ES5776","description":"\u003cp\u003eHistamine H1 Receptor (phospho Ser398) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5776-50, ES5776-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HRH1, Histamine H1 receptor, H1R, HH1R\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Histamine H1 Receptor around the phosphorylation site of Ser398. AA range:364-413\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Histamine H1 Receptor\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Histamine H1 Receptor (S398) Polyclonal Antibody detects endogenous levels of Histamine H1 Receptor protein only when phosphorylated at S398.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Lens epithelium, Lung,\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight (Da): 56kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system\u003cbr\u003e\nPTM: Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule\u003cbr\u003e\nSimilarity: Belongs to the G-protein coupled receptor 1 family\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: HRH1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Histamine H1 receptor\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 15465\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P70174\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 24448\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P31390\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313566372019,"sku":"ES5776-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313566404787,"sku":"ES5776-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/histamine-h1-receptor-phospho-ser398-rabbit-polyclonal-antibody-es5776","provider":"AFSBio Inc.","version":"1.0","type":"link"}