{"product_id":"histone-h2a-x-phospho-thr120-rabbit-polyclonal-antibody-es20579","title":"Histone H2A.X (Phospho Thr120) Rabbit Polyclonal Antibody - ES20579","description":"\u003cp\u003eHistone H2A.X (Phospho Thr120) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20579-50, ES20579-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: H2AFX, H2AX, Histone H2A.x, H2a\/x\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of Histone H2A.X (Phospho Thr120)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Histone H2A.X\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The antibody detects endogenous Histone H2A.X (Phospho Thr120) protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormlation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Lung, Placenta,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 15kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus\u003c\/p\u003e\n\n\u003cp\u003eFunction: Developmental Stage: Synthesized in G1 as well as in S-phase\u003cbr\u003e\nDomain: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3\/PI4-kinase family\u003cbr\u003e\nFunction: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation\u003cbr\u003e\nPTM: Mon\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Chromosome\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: H2AFX\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Histone H2A.x\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 15270\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P27661\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314184278195,"sku":"ES20579-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314184310963,"sku":"ES20579-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/histone-h2a-x-phospho-thr120-rabbit-polyclonal-antibody-es20579","provider":"AFSBio Inc.","version":"1.0","type":"link"}