{"product_id":"histone-h2b-di-methyl-lys43-rabbit-polyclonal-antibody-es20560","title":"Histone H2B (Di Methyl Lys43) Rabbit Polyclonal Antibody - ES20560","description":"\u003cp\u003eHistone H2B (Di Methyl Lys43) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20560-50, ES20560-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis\/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: H2BK43ME2, HIST1H2BA, TSH2B, Histone H2B type 1-A, Histone H2B, testis, Testis-specific histone H2B, HIST1H2BB, H2BFF, Histone H2B type 1-B, Histone H2B.1, Histone H2B.f, H2B\/f, HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2BI, H2BFK, Histone H2B type 1-C\/E\/F\/G\/I, Histone H2B.1 A, Histone H2B.a, H2B\/a, Histone H2B.g, H2B\/g, Histone H2B.h, H2B\/h, Histone H2B.k, H2B\/k, Histone H2B.l, H2B\/l\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of Histone H2B (Di Methyl Lys43)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Histone H2B\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The antibody detects endogenous Histone H2B (Di Methyl Lys43) protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500-1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormlation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level), Also found in some fat cells,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 14kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling\u003cbr\u003e\nPTM: Monoubiquitination of Lys-122 by the RNF20\/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II\u003cbr\u003e\nSimilarity: Belongs to the histone H2B family\u003cbr\u003e\nSubunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Chromosome\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: HIST1H2BC\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Histone H2B type 1-A\/Histone H2B type 1-B\/Histone H2B type 1-C\/E\/F\/G\/I\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 319177\/319178\/319179\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 24829\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q00729\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314182934707,"sku":"ES20560-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314182967475,"sku":"ES20560-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/histone-h2b-di-methyl-lys43-rabbit-polyclonal-antibody-es20560","provider":"AFSBio Inc.","version":"1.0","type":"link"}