{"product_id":"hla-doβ-polyclonal-antibody-ra25966","title":"HLA-DOβ Polyclonal Antibody - RA25966","description":"\u003cp\u003eHLA-DOβ Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA25966-50, RA25966-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: major histocompatibility complex, class II, DO beta (HLA-DOB) Homo sapiens HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 3112\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 30\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P13765\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121331790003,"sku":"RA25966-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121331822771,"sku":"RA25966-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_40f66ef5-4577-4652-bfac-7bf3b4dc8368.png?v=1773346528","url":"https:\/\/afsbio.com\/products\/hla-do%ce%b2-polyclonal-antibody-ra25966","provider":"AFSBio Inc.","version":"1.0","type":"link"}