{"product_id":"hla-dr-rabbit-polymab®-a26694pm","title":"HLA-DR Rabbit PolymAb® - A26694PM","description":"\u003cp\u003eHLA-DR Rabbit PolymAb®\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A26694PM-20, A26694PM-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes\/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\/ICC, IF-P, IHC-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 29kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 30-40kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3122\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01903\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HLA-DRA1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:1000 - 1:4000 IF\/ICC, 1:200 - 1:800 IF-P, 1:200 - 1:800 IHC-P, 1:400 - 1:4000 ELISA, Recommended starting concentration is 1 µg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Immunology Inflammation.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: HLA-DRA\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189883166899,"sku":"A26694PM-20","price":165.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189883199667,"sku":"A26694PM-100","price":431.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_5cf0a701-58b9-4130-a3f4-3f8aefbb3cf0.png?v=1766437402","url":"https:\/\/afsbio.com\/products\/hla-dr-rabbit-polymab%c2%ae-a26694pm","provider":"AFSBio Inc.","version":"1.0","type":"link"}