{"product_id":"hla-g-monoclonal-antibody-mb66909","title":"HLA-G Monoclonal Antibody-MB66909","description":"\u003cp\u003eHLA-G Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66909-50, MB66909-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P17693\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: HLA-G  is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors.Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte\/macrophage cells . Its involvement in evasion of immune response makes it a potential target for immunotherapy.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of HLA-G protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of HLA-G expression in A549 (A), Ramos (B), MDAMB231 (C) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 43  kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: HLA-6.0; HLAG; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; MHC class I antigen G\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human HLA-G. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906392690867,"sku":"MB66909-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906392723635,"sku":"MB66909-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1976c086-dfa8-4a4f-874a-0eed71535af7.jpg?v=1702918998","url":"https:\/\/afsbio.com\/products\/hla-g-monoclonal-antibody-mb66909","provider":"AFSBio Inc.","version":"1.0","type":"link"}