{"product_id":"hmga2-polyclonal-antibody-bt-ap10085","title":"HMGA2 Polyclonal Antibody - BT-AP10085","description":"\u003cp\u003eHMGA2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10085-20, BT-AP10085-50, BT-AP10085-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Developmental biology; Epigenetics and nuclear signaling; Neuroscience; Stem cells; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: HMGA2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: High mobility group protein HMGI-C\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P52926; Mouse: P52927\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: High mobility group protein HMGI-C;High mobility group AT-hook protein 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8091\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239168925875,"sku":"BT-AP10085-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239168958643,"sku":"BT-AP10085-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239168991411,"sku":"BT-AP10085-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_02c7466d-6d5a-4238-990a-94ed5e04e55b.png?v=1769390071","url":"https:\/\/afsbio.com\/products\/hmga2-polyclonal-antibody-bt-ap10085","provider":"AFSBio Inc.","version":"1.0","type":"link"}