{"product_id":"hmgcr-polyclonal-antibody-bs90652","title":"HMGCR Polyclonal Antibody-BS90652","description":"\u003cp\u003eHMGCR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90652-50, BS90652-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P04035(Human) Q01237(Mouse) P51639(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of HMGCR on Hela cellsLysates using anti-HMGCR antibody at 1\/1,000 dilution.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 97 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HMGCR polyclonal antibody detects endogenous levels of HMGCR protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: HMG-CoA reductase, HMGCR, 3 hydroxy 3 methylglutaryl CoA reductase, 3 hydroxy 3 methylglutaryl Coenzyme A reductase, 3 hydroxymethylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3H3M, HMDH, HMG CoA reductase, HMG CoAR, HMG-CoA reductase, Hmgcr, Hydroxymethylglutaryl CoA reductase, LDLCQ3, MGC103269, Red,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939200405683,"sku":"BS90652-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939200438451,"sku":"BS90652-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e5babf58-ef59-4755-a654-120cf20a3563.jpg?v=1704545017","url":"https:\/\/afsbio.com\/products\/hmgcr-polyclonal-antibody-bs90652","provider":"AFSBio Inc.","version":"1.0","type":"link"}