{"product_id":"hnf-4α-γ-acetyl-lys127-79-rabbit-polyclonal-antibody-es8629","title":"HNF-4α\/γ (Acetyl Lys127\/79) Rabbit Polyclonal Antibody - ES8629","description":"\u003cp\u003eHNF-4α\/γ (Acetyl Lys127\/79) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8629-50, ES8629-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)(TCF-14) (Transcription factor HNF-4)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Acetyl peptide from human protein at AA range: 127(HNF-4α)\/79(HNF-4γ)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: HNF-4α\/γ\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of HNF-4α\/γ at Human:K127\/79, Mouse:K127\/79, Rat:K127, It doesn't reacte with total protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Kidney, Liver,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 55kD\u003c\/p\u003e\n\n\u003cp\u003eFields: AMPK signaling pathway, Maturity onset diabetes of the young\u003c\/p\u003e\n\n\u003cp\u003eFunction: Alternative Products: Additional isoforms seem to exist,Disease: Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM: 125850], also shortened MODY-1. MODY [MIM: 606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications\u003cbr\u003e\nFunction: Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine\u003cbr\u003e\nMiscellaneous: Binds fatty acids\u003cbr\u003e\nOnline Information: Hepatocyte nuclear fac\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: HNF4A HNF4 NR2A1 TCF14 HNF4G NR2A2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Hepatocyte nuclear factor 4-alpha\/gamma (HNF-4-alpha\/gamma) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313871311027,"sku":"ES8629-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313871343795,"sku":"ES8629-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/hnf-4%ce%b1-%ce%b3-acetyl-lys127-79-rabbit-polyclonal-antibody-es8629","provider":"AFSBio Inc.","version":"1.0","type":"link"}