{"product_id":"hnf1-alpha-monoclonal-antibody-mb66924","title":"HNF1 alpha Monoclonal Antibody - MB66924","description":"\u003cp\u003eHNF1 alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66924-50, MB66924-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Hepatocyte nuclear factor 1伪 is a transcription factor that plays a role in the tissue-specific regμlation of liver gene expression. Research has shown that heterogeneous mutations of HNF1伪 are linked to maturity onset diabetes of the young . Recent studies indicate that increased concentrations of free fatty acids can reduce the expression of FoxA2\/HNF3尾 and HNF1伪 in pancreatic 尾-cells and lead to their nuclear exclusion, resμlting in symptoms of several metabolic syndromes .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TCF1, Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, Transcription factor 1, TCF-1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HNF1 alpha. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of HNF1 alpha protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 81 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling, Wntβ catenin signaling\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P20823\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946157400243,"sku":"MB66924-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946157433011,"sku":"MB66924-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/hnf1-alpha-monoclonal-antibody-mb66924","provider":"AFSBio Inc.","version":"1.0","type":"link"}