{"product_id":"hnrnp-q-polyclonal-antibody-bs90657","title":"hnRNP Q Polyclonal Antibody-BS90657","description":"\u003cp\u003ehnRNP Q Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90657-50, BS90657-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O60506(Human) Q7TP47(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:2,000\u003cbr\u003e\nICC:1:50-1:200\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: hnRNP Q polyclonal antibody detects endogenous levels of hnRNP Q protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 70 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of hnRNP Q on K562 cell lysate using anti-hnRNP Q antibody at 1\/1,000 dilution., ICC staining hnRNP Q in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1, cytoplasmic RNA-interacting protein, dJ3J17.2, Glycine and tyrosine rich RNA binding protein, Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, GRYRBP, Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, HNRPQ, HNRPQ, HNRPQ1, NS1 associated protein 1, NS1-associated protein 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin binding cytoplasmic RNA interacting protein, Synaptotagmin-binding, Syncrip,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein to C-terminal human hnRNP Q.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984576450739,"sku":"BS90657-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984576483507,"sku":"BS90657-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_aca13fad-aada-42b2-9fe6-d95faf241f07.jpg?v=1705918583","url":"https:\/\/afsbio.com\/products\/hnrnp-q-polyclonal-antibody-bs90657","provider":"AFSBio Inc.","version":"1.0","type":"link"}