{"product_id":"hsd17b4-polyclonal-antibody-bs60710","title":"HSD17B4 Polyclonal Antibody-BS60710","description":"\u003cp\u003eHSD17B4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60710-50, BS60710-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2; HSD17B4; EDH17B4\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P51659\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme\/protein 2 (MFE-2\/MFP-2), D-bifunctional enzyme or 17-β Estradiol 17β-HSD4 (17β-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme\/protein 2 (MFE-2\/MFP-2), D-bifunctional enzyme or 17-β Estradiol dehydrogenase type IV. It belongs to the 17β-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17β-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol β-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17β-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17β-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: HSD17B4 polyclonal antibody detects endogenous levels of HSD17B4 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 79 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of HSD17B4 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: HEK293T whole cell lysate\u003cbr\u003e\nLane 2: Raw264.7 whole cell lysate \u003cbr\u003e\nLane 3: PC12 whole cell lysate\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: A synthetic peptide corresponding to residues in Human HSD17B4\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42913741340851,"sku":"BS60710-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42913741373619,"sku":"BS60710-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e20a0b42-d572-44d1-950c-ae7ab2d5cb7c.jpg?v=1703266858","url":"https:\/\/afsbio.com\/products\/hsd17b4-polyclonal-antibody-bs60710","provider":"AFSBio Inc.","version":"1.0","type":"link"}