{"product_id":"hsp-90-rabbit-polyclonal-antibody-es4057","title":"HSP 90 Rabbit Polyclonal Antibody - ES4057","description":"\u003cp\u003eHSP 90 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4057-50, ES4057-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human HSP90A\/B around the non-acetylation site of Lys292\/284. AA range:251-300\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: HSP 90,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: HSP 90 Polyclonal Antibody detects endogenous levels of HSP 90 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1\/100-1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Adult brain, Brain, Brain cortex, Breast, Cajal-Retzius\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Necroptosis, Antigen processing and presentation, NOD-like receptor signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Salmonella infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Caution: Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence. Molecular chaperone. Molecular chaperone. Has ATPase activity. Similarity: Belongs to the heat shock protein 90 family. Subcellular Location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Subunit: Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Melanosome Cell membrane Mitochondrion Identified by mass spectrometry in melanosome fractions from stage I to stage IV.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: HSP90AA1\/HSP90AB1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Heat shock protein HSP 90-alpha\/Heat shock protein HSP 90-beta\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 3326\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P07900\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 15519\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P07901\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 299331\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P82995\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825502740659,"sku":"ES4057-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825502773427,"sku":"ES4057-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/hsp-90-rabbit-polyclonal-antibody-es4057","provider":"AFSBio Inc.","version":"1.0","type":"link"}