{"product_id":"hsp70-monoclonal-antibody-mb66497","title":"HSP70 Monoclonal Antibody - MB66497","description":"\u003cp\u003eHSP70 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66497-50, MB66497-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: HSP70 and HSP90 are molecμlar chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress . Both HSP70 and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner . HSP70 has a broad range of substrates including newly synthesized and denatured proteins, while HSP90 tends to have a more limited subset of substrates, most of which are signaling molecμles. HSP70 and HSP90 often function collaboratively in a mμlti-chaperone system, which requires a minimal set of co-chaperones: HSP40, Hop, and p23 . The co-chaperones either regμlate the intrinsic ATPase activity of the chaperones or recruit chaperones to specific substrates or subcellμlar compartments . When the ubiquitin ligase CHIP associates with the HSP70\/HSP90 complex as a cofactor, the unfolded substrates are subjected to degradation by the proteasome . The biological functions of HSP70\/HSP90 extend beyond their chaperone activity. They are essential for the maturation and inactivation of nuclear hormones and other signaling molecμles. They also play a role in vesicle formation and protein trafficking .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HSP72, HSPA1, HSX70, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1, HSP70-1, HSP70.1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant human Hsp70(C-terminus) protein fragments expressed in E.coli.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IP (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of HSP70 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 70 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Inhibition of Apoptosis\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P0DMV8\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946405224627,"sku":"MB66497-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946405257395,"sku":"MB66497-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/hsp70-monoclonal-antibody-mb66497","provider":"AFSBio Inc.","version":"1.0","type":"link"}