{"product_id":"hsp90b-mouse-monoclonal-antibody-mb9019","title":"HSP90B Mouse Monoclonal Antibody-MB9019","description":"\u003cp\u003eHSP90B Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB9019-50, MB9019-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG2a, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P08238\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:5000 \u003cbr\u003e\nIHC: 1:100-1:200\u003c\/p\u003e \n\n\u003cp\u003eBackground: HSP 90 family members guide the normal folding, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. HSP 90alpha, also designated HSP90A, HSP 86 and LPS-associated protein 2 (LAP2), is a cytosolic enhancer of inducible nitric-oxide synthase (iNOS), with chaperone activity that is important for the transcriptional activity of p53. HSP 90beta, also designated HSP90B, HSP 84 and HSPC2, is a cytosolic protein that participates in signaling pathways with PKC epsilon to protect cells from external damage, particularly in heat shock-mediated events. GRP 94, also known as tumor rejection antigen 1 (TRA1), ECGP and GP96, localizes to the ER, is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein A affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of HSP90B and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 90 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of HSP90B Mouse mAb at 1:5000 dilution\u003cbr\u003e\n Lane 1: Hela whole cell lysate\u003cbr\u003e\n Lane 2: NIH\/3T3 whole cell lysate\u003cbr\u003e\n Lane 3: PC12 whole cell lysate\u003cbr\u003e\n Lane 4: 293T whole cell lysate\u003cbr\u003e\n Lane 5: HepG2 whole cell lysate\u003cbr\u003e\n Lane 6: COS-1 whole cell lysate\u003cbr\u003e\n Lane 7: Jurkat whole cell lysate\u003cbr\u003e\n Lane 8: A549 whole cell lysate\u003cbr\u003e\n Lane 9: Raji whole cell lysate\u003cbr\u003e\n Lane 10: The heart tissue lysate of Mouse, Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti-HSP90B antibody. Counter stained withhematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84; HSP90AB1; HSP90B; HSPC2; HSPCB\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to HSP90B.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42987071570099,"sku":"MB9019-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42987071602867,"sku":"MB9019-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_034a4820-44e4-4164-bd75-60d06dfc5b15.jpg?v=1706008488","url":"https:\/\/afsbio.com\/products\/hsp90b-mouse-monoclonal-antibody-mb9019","provider":"AFSBio Inc.","version":"1.0","type":"link"}