{"product_id":"htra1-polyclonal-antibody-e-ab-40659","title":"HTRA1 Polyclonal Antibody - E-AB-40659","description":"\u003cp\u003eHTRA1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40659-50, E-AB-40659-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HTRA1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Serine protease HTRA1; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; PRSS11\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q92743\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.5mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human HTRA1 protein expressed by E.coli\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB:1:250-1:500\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 51 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 51 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149048021171,"sku":"E-AB-40659-50","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149048053939,"sku":"E-AB-40659-100","price":322.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0bbcc336-7608-4127-87bb-98a73c756ef7.png?v=1710339231","url":"https:\/\/afsbio.com\/products\/htra1-polyclonal-antibody-e-ab-40659","provider":"AFSBio Inc.","version":"1.0","type":"link"}