Mouse monoclonal antibody to native human Adiponectin. Two clones are available (5E4 and 4F11), which can be used independently or as a capture-detection pair. Antibodies are suitable for applications such as Adiponectin immunoassays, ELISA, ICC, ICC/IF, IHC-P and WB. Adiponectin is a 247-amino acid protein-hormone which regulates glucose and fatty acids metabolism. In humans, it is produced by the adipose tissue and secreted into the blood stream.
|Product Data Sheet||Download PDF|
|Package Size:||0.25 mg|
|Other names:||Antibody to human Adiponectin, ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC, adipocyte, C1Q and collagen domain containing; ACRP30; AdipoQ.|
|Clonality:||Monoclonal (Two clones are available independently or as a pair: 5E4 and 4F11)|
|Purification:||Chromatography on protein A Sepharose|
|Preservative:||0.05% sodium azide|
|Storage:||2-8°C (short term), -20°C (long term). Avoid repeated freeze-thaw.|
Adiponectin has been shown to increase insulin sensitivity and low levels of Adiponectin have been correlated to insulin resistance. In addition, Adiponectin is involved in many pathways that include Adipocytokine signaling pathway, Adipogenesis, Developmental Biology, PPAR signaling pathway, PPAR signaling pathway and Transcriptional Regulation of White Adipocyte Differentiation.
- Takeda, Y., Nakanishi, K., Tachibana, I., and Kumanogoh, A. (2012). Adiponectin. Adiponectin Vitamins & Hormones, 419–435.
- Juhl, C., & Beck-Sickinger, A. G. (2012). Molecular Tools to Characterize Adiponectin Activity. Adiponectin Vitamins & Hormones, 31–56.
- Palin, M.-F., Bordignon, V. V., and Murphy, B. D. (2012). Adiponectin and the Control of Female Reproductive Functions. Adiponectin Vitamins & Hormones, 239–287.
- Lustig, Y., Hemi, R., and Kanety, H. (2012). Regulation and Function of Adiponectin Receptors in Skeletal Muscle. Adiponectin Vitamins & Hormones, 95–123.
- Heiker, J. T., Kosel, D., and Beck-Sickinger, A. G. (2010). Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors. Biological Chemistry, 391(9).