{"product_id":"human-pro-collagen-i-alpha-rabbit-pab-a24863","title":"Human Pro-Collagen I alpha Rabbit pAb - A24863","description":"\u003cp\u003eHuman Pro-Collagen I alpha Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24863-20, A24863-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.\u003c\/p\u003e \n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF-P, IHC-P\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 138kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 220kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1277\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P02452\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: COL1A1; EDSC; OI1; OI2; OI3; OI4; collagen alpha-1 (I) chain; Human Pro-Collagen I alpha\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:1000 - 1:5000 IF-P, 1:50 - 1:200 IHC-P, 1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Cytoskeleton \/ ECM, Extracellular Matrix, ECM Proteins, Collagen.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: COL1A1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189859573939,"sku":"A24863-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189859606707,"sku":"A24863-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_77465c90-0633-4f47-bc98-95eb7ac7e03b.png?v=1766436927","url":"https:\/\/afsbio.com\/products\/human-pro-collagen-i-alpha-rabbit-pab-a24863","provider":"AFSBio Inc.","version":"1.0","type":"link"}