{"product_id":"huwe1-polyclonal-antibody-ra32699","title":"HUWE1 Polyclonal Antibody - RA32699","description":"\u003cp\u003eHUWE1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA32699-50, RA32699-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) Homo sapiens This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)) . This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section)\u003c\/p\u003e \n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 10075\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 481\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q7Z6Z7\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120484442291,"sku":"RA32699-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120484475059,"sku":"RA32699-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_71a9bf84-7706-4797-8bff-90b28e31f694.png?v=1773366451","url":"https:\/\/afsbio.com\/products\/huwe1-polyclonal-antibody-ra32699","provider":"AFSBio Inc.","version":"1.0","type":"link"}